• Peritoneal metastasis

What is metastatic peritoneal cancer ?

Peritoneum is the tissue that lines the abdominal wall and covers most of the organs in the abdomen. A liquid, peritoneal fluid, lubricates the surface of this tissue.

  • Peritoneal metastasis occur when cancer has spread to the peritoneum from other organs.
  • The peritoneum is a common site of metastasis for gastric, ovarian or colorectal cancer.
  • Peritoneal cancer is also called peritoneal carcinomatosis

To learn more about peritoneal metastasis.

Peritoneal metastasis

Around 1

porcents of peritoneal metastasis come from ovarian cancer

More than 7800

peritoneal carcinomatosis in colorectal cancer in US per year

peritoneal metastasis diagnosis

How to detect peritoneal metastasis ?

Metastatic cancers of the peritoneum being secondary to another cancer, they are often poorly diagnosed. To diagnose peritoneal metastasis, the following examinations coupled with a consultation with a specialist are required :

  • CT Scan: to provide appropriate site-specific cancer involvement in the abdominal cavity
  • MRI: It is also one of the diagnostic tools for detecting peritoneal metastasis. However, it has not shown any significant superiority over CT scanning
  • PET-CT scan is more useful than just a PET scan, as the addition of CT allows for better anatomic visualization.
  • Diagnostic Laparoscopy:  for the assessment of the resectability of peritoneal tumor nodules before undergoing cytoreductive surgery.

What are the treatments for peritoneal metastasis ?

To date Intra Peritoneal chemotherapy is always used in support to cytoreductive surgery. 5 types of intraperitoneal chemotherapy exist and differ by their timing of administration :

  • Hyperthermic Intraperitoneal Chemotherapy (HIPEC): administration of the chemotherapy solution heated at 43-45°C
  • Early Postoperative Chemotherapy (EPIC): A large volume of chemotherapy is instilled during surgery.
  • Normothermic Intraperitoneal Chemotherapy (NIPEC): Large volumes are gradually instilled and many cycles of treatment can be performed.
  • Neoadjuvant Intraperitoneal and Systemic drugs (NIPS): consists of preparing the patient to facilitate cytoreductive surgery toward a complete resection.
  • Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC): to deliver chemotherapy in the form of a pressurized aerosol into the abdomen.

metastatic peritoneal cancer treatment

Device for the administration of chemotherapy agents

Principle of ExOlin ®

  • A medical device for the delivery of a chemotherapy agents
  • Instant site specific delivery  of the molecule of interest
  • Reduced toxicity of anti-cancer treatments
  • Adaptable to many applications and pathologies, other than peritoneal cancer, that require physiological delivery of drugs or active ingredients

This application of the ExOlin device is currently in the exploratory stage.

 

About Defymed About ExOlin®