The iNanoBIT project is aimed to apply nanotechnologies for imaging porcine pancreatic islet cellular transplants and induced pluripotent stem cell-derived beta-cells and subsequent regenerative processes in vivo in a porcine model.
The iNanoBIT project will provide the currently missing toolbox for preclinical/clinical testing for a safe translation of regenerative medicinal cellular and tissue products, currently under preclinical and clinical trials, which is vital for the competitiveness of the European healthcare sector in this fast-growing area.
allowing for monitoring of survival, engraftment, proliferation, function and whole body distribution of the cellular transplants in a preclinical porcine model with excellent translational potential to humans
facilitating the provision of new regenerative therapies to preclinical large animal models and patients
Nano-imaging tools - nanotools allowing multimodality imaging of specific cell types with high sensitivity
Imaging equipment development - dedicated SPECT systems combined with CT and optoacoustic imaging in preclinical large animal models and patients
Application of a medical device for transplantation of stem cell-derived beta-cells or xenogeneic islets
Development of transplantable in vitro differentiated human beta-cells and porcine xenogeneic islets