The iNanoBIT project is aimed to apply nanotechnologies for imaging porcine pancreatic islet cellular transplants and induced pluripotent stem cell-derived beta-cells and subsequent regenerative processes in vivo in a porcine model.

The iNanoBIT project will provide the currently missing toolbox for preclinical/clinical testing for a safe translation of regenerative medicinal cellular and tissue products, currently under preclinical and clinical trials, which is vital for the competitiveness of the European healthcare sector in this fast-growing area.

The project aims to develop:

01.

Novel highly sensitive nanotechnology-based imaging approaches

allowing for monitoring of survival, engraftment, proliferation, function and whole body distribution of the cellular transplants in a preclinical porcine model with excellent translational potential to humans

02.

Develop and validate the application of state-of-the-art imaging technologies

facilitating the provision of new regenerative therapies to preclinical large animal models and patients

03.

Directly contribute to the opening of a new market sector for:

  • imaging equipment (SPECT, PET/MR, optoacoustic imaging in preclinical large animal models and patients),
  • nano-imaging molecule supplies (nanomolecules allowing multimodality imaging of specific cell types with high sensitivity),
  • validated transplantable in vitro differentiated human beta-cells and porcine xenotransplant islets thus will reinforce the European healthcare supply chain for regenerative medicinal products.

iNanoBIT project

Nano-imaging tools - nanotools allowing multimodality imaging of specific cell types with high sensitivity

Imaging equipment development - dedicated SPECT systems combined with CT and optoacoustic imaging in preclinical large animal models and patients

Application of a medical device for transplantation of stem cell-derived beta-cells or xenogeneic islets

Development of transplantable in vitro differentiated human beta-cells and porcine xenogeneic islets