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iNanoBIT
The iNanoBIT project is aimed to apply nanotechnologies for imaging porcine pancreatic islet cellular transplants and induced pluripotent stem cell-derived beta-cells and subsequent regenerative processes in vivo in a porcine model.
The iNanoBIT project will provide the currently missing toolbox for preclinical/clinical testing for a safe translation of regenerative medicinal cellular and tissue products, currently under preclinical and clinical trials, which is vital for the competitiveness of the European healthcare sector in this fast-growing area.
The project aims to develop:
Novel highly sensitive nanotechnology-based imaging approaches
allowing for monitoring of survival, engraftment, proliferation, function and whole body distribution of the cellular transplants in a preclinical porcine model with excellent translational potential to humans
Develop and validate the application of state-of-the-art imaging technologies
facilitating the provision of new regenerative therapies to preclinical large animal models and patients
Directly contribute to the opening of a new market sector for:
- imaging equipment (SPECT, PET/MR, optoacoustic imaging in preclinical large animal models and patients),
- nano-imaging molecule supplies (nanomolecules allowing multimodality imaging of specific cell types with high sensitivity),
- validated transplantable in vitro differentiated human beta-cells and porcine xenotransplant islets thus will reinforce the European healthcare supply chain for regenerative medicinal products.
iNanoBIT project
Nano-imaging tools - nanotools allowing multimodality imaging of specific cell types with high sensitivity
Imaging equipment development - dedicated SPECT systems combined with CT and optoacoustic imaging in preclinical large animal models and patients
Application of a medical device for transplantation of stem cell-derived beta-cells or xenogeneic islets
Development of transplantable in vitro differentiated human beta-cells and porcine xenogeneic islets
