A medical device for the encapsulation of insulin-secreting cells, under development for the treatment of type 1 diabetes
Possibility of replacing the cells without the need for surgery, thanks to an input and output connection to the device
Use of non-biodegradable, biocompatible membranes with selective permeability: the glucose and insulin pass freely through the membrane while the immune system of the recipient [such as antibodies] cannot get inside the device
Adaptable to cell therapies (for diabetes and other applications), which require a protection of the immune system.
02.Advantages of a BioArtificial Pancreas:
Immune-protective membranes, which mean that onerous immunosuppressive therapies are no longer needed for the cell therapy of diabetes patients, e.g. human pancreatic islet transplantation
Unlimited access to insulin-secreting cells, thanks especially to the use of stem cells = no longer any need to rely on human pancreas donors
The autonomous and physiological regulation of blood glucose because the cells detect the level of glucose in the blood and release the required amount of insulin